TRIACANA 0.35 mcg (3,5,3?-triiodothyroacetic acid - Tiratricol) description, TRIACANA 0.35 mcg (3,5,3?-triiodothyroacetic acid - Tiratricol) side effects, TRIACANA 0.35 mcg (3,5,3?-triiodothyroacetic acid - Tiratricol) price, TRIACANA 0.35 mcg (3,5,3?-triiodothyroacetic acid - Tiratricol) substance
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Active ingredients: Tiratricol
Indications: Obesity
Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.
TRIACANA Uses
It is indicated in the management of thyroid hormone resistance syndrome and is used, in combination with levothyroxine, to suppress thyroid-stimulating hormone production in patients with thyroid cancer.
It has been investigated for use in reducing goiter.
It has also shown some effectiveness in reducing the atrophy caused when using corticosteroids.
Tiratricol has also been widely marketed, under various trade names, as a weight loss aid. In 1999 and 2000, the United States Food and Drug Administration and Health Canada both issued warnings to the public regarding the use of dietary supplements containing tiratricol.
TRIACANA Legal status
Tiratricol is not approved for sale in Canada or the United States. It was once an approved drug in Brazil, but its marketing authorization was suspended in 2003, effectively prohibiting its sale. Tiratricol is still available in France for therapy of thyroid hormone resistance and adjuvant therapy of thyroid cancer. It is available as an orphan drug to be prescribed by registered specialists in Europe.
Triacana belongs to the group of thyroid hormone preparations. Its substance tiratricol is a precursor of the iodiferous thyroid hormone, L-triiodthyronine (L-T3). L-T3, together with another iodiferous thyroid hormone, L-T4 (L-thyroxine), is produced in the thyroid and is the distinctly stronger and more effective of these two hormones. School medicine use Triacana in the treatments of obesity and hyperthyroidism (e.g. Jod-Basedow phenomenon-, goiter). Hyperthyroidism is an abnormal function of the thyroid gland in which the amount of secretion by the thyroid hormone is above average. The thyroid-stimulating hormone (TSH) stimulates the thyroid gland to
produce more L-T3 and L-T4. By the use of Triacana an excessive release of TSH can be avoided.
In the medical arsenal of bodybuilders Triacana has had a firm place since the late 1970's. After all, its lipolytic (fatburning) effect is sufficiently known. This is due to the hypermetabolic state, increased
irritability, and especially higher body temperature (generation of
heat) during tshe intake of Triacana. These are factors, which help the
competing bodybuilder break down fat more easily. By a caloric intake
which is higher than usual it is still possible to obtain a lower body
fat content together with good muscle hardness. Although Triacana enjoys
the reputation among athletes as a strong and especially effective
fatburning thyroid hormone preparation, this preparation is a rather
mild, well tolerated and relatively harmless compound. The often-made
comparison with the two L-T3 thyroid gland hormone compounds, Cytomel
and Thybon, is a poor comparison since Triacana, mi-crogram for
microgram, has a considerably lower effect. Even the more moderate L-T4
thyroid hormone drugs such as Synthroid or L-thyroxine are stronger than
the substance tiratricol.
In order to achieve a visible fat-reducing effect most athletes must
usually take 10-14 tablets/day. Generally, two 0.35 mg tablets are taken
on the first day of intake and with two tablets added each successive
day until 10-14 tablets/day are taken. The half-life time of tiratricol
is 5-7 hours, so Triacana is usually taken 3-4 times daily. This
guarantees a constant quantity of the sub-stance in the blood and thus a
continued effect. Many athletes, in the meantime, are combining Triacana
with Clenbuterol or Ephedrine and report considerably better fat
breakdown than when Triacana alone is taken. Among competing female
bodybuilders and participants at the Miss Fitness pageant, in
particular, the simultaneous administration of 8-10 Triacana tablets/day
and 80-100 mcg Clenbuterol/day is a favorite. A series of bodybuilders
use Triacana in combination with growth hormones in order to meet the
body's increased thyroid hormone need during STH treatment (see chapter
"Growth Hormones"). The theoretical approach seems to be correct but
Triacana is not an "ideal" thyroid hormone drug. The preparation
Thyreocomb from the German Berlin-Chemie Company taken with a
combination of the iodiferous L-T3 and L-T4 thyroid hormones would be
more suit-able.
As for the duration of application the opinions of athletes vary
greatly. Some use Triacana for only 4 weeks, mostly because they are
afraid of a thyroid dysfunction. Others take it over a period of months.
When looking at the physiological characteristics of the substance
tiratricol, it becomes easier to make more accurate indications as to a
possible duration of intake and the potential health risks that go along
with the use. When taken in a dosage of 0.6 mg/day the reduction in the
body's own TSH release can be obtained; with increased dosages it can be
completely suppressed. The fear that the TSH release will be
continuously disturbed or suppressed after using the medication is
with-out reason since this is a reversible, temporary process. 'Already
2-3 weeks after the intake is discontinued the TSH release is completely
normalized" (from Vidal 1994, page 1498). With this back-ground
knowledge and based on the experiences of several athletes we would
choose an intake interval of 10- 12 weeks.
Potential side effects such as palpitations, tremors, irregular
heartbeat, dizziness, restlessness, nervousness, and excessive
perspiration occur mostly during the first few days of intake. Those who
in-crease their dosages slowly and evenly over several days as suggested
usually have few problems with Triacana. Toward the end of the intake
period a step-by-step reduction in the daily tablet dosage is better
than abruptly discontinuing the substance. In summary one can say that
Triacana is a (mild) alternative to the strong L-T3 thyroid hormone
compounds such as Cytomel or Thybon with their strong side effects. It
has only a lower lipolytic effect but can be taken over a prolonged
period of time. Mistakes made during the intake are forgiven with
Triacana rather than with Cytomel. Ambitious bodybuilders and athletes
who are able to responsibly use strong medication choose Cytomel;
persons who, however, fear side effects, who do not know much, or
believe that "more is better," should select Triacana.
The Thyroid Gland Part 2 — How to Renew its Activity During a Diet
By Michael Gundill & Leave a Comment
The thyroid gland and the hormones that it produces are among the key factors which determine the success or failure of a diet. Because thyroid hormones are regulators of basal metabolism, they determine the daily consumption of calories. A strict diet downregulates the activity of the gland. This lowers the daily requirement in calories, obliging us to eat still less. It can be a vicious cycle.
There are many strategies to deal with this situation. Often, bodybuilders use unusual or unapproved methods. After having discussed the most popular, we will suggest a natural alternative which is much healthier.
It is therefore fair to ask the following question:
Therefore for the duration of a diet, Triac is going to prevent fat loss rather than helping it.If we had a natural method of preventing T3 from being degraded to Triac, we would be able to lose fat faster and more easily with fewer harmful consequences to the thyroid gland. Moreover, without Triac, muscular catabolism during a diet will be less. Which is far from the promises of the black market dealers.
Why is this difference between the inhibiting action on TSH and the peripheral actions of Triac so pronounced?
Here also, the researchers have an answer. They have shown that Triac has a greater affinity for T3 receptors than T3 itself. This means that the thyroid hormone receptors are going to prefer to be activated by Triac than by T3. This would mean that Triac is more powerful than T3. Yet as we have seen, Triac is less powerful than T3 with regards to peripheral effects.
This is in regard to peripheral receptors. On the other hand, in the brain, Triac has a much more powerful inhibiting effect than the other thyroid hormones. Because conversion of T4 into T3 is increased in brain tissue when we diet [5], there is more T3 for conversion to Triac. Result: the brain is fooled, and is made to think that there is a high level of thyroid hormones in the blood. The secretion of TSH is therefore going to be inhibited. For those who are interested, they will find at the end of this article a detailed bibliography.
Now it is fair to ask the following question:
In the case of bodybuilders, all the other thyroid extracts are superior to Triacana. Obviously, one must not forget that during a diet, the transformation of T4 into T3 deteriorates, and that even a supplementation in either T3 or T4 is going to increase the level of Triac.
Medline
Abstract:
3,5,3'-triiodothyroacetic acid therapy for thyroid hormone resistance.
3,5,3'-Triiodothyroacetic Acid (Triac) is reputed to suppress pituitary secretion of TSH with minimal metabolic effects. Triac has been used successfully to treat eight patients with thyroid hormone resistance. We gave Triac to a woman with selective pituitary resistance for treatment of hyperthyroidism (patient 1) and to a man with generalized resistance and chronic schizophrenia to determine whether it would improve his schizophrenia (patient 2). Patient 1 was given 0.35-3.5 mg Triac/day; patient 2 was given 0.7-4.2 mg/day. Dosages were increased by 0.7 mg/day every 2 weeks. Serum T3, T4, free T4, TSH, TSH response to TRH, systolic time intervals (STI), angiotensin-converting enzyme (ACE), and lipids were monitored bimonthly. In both patients, there was no change in symptoms, weight, lipids, or STI. In patient 1, basal TSH suppressed from 16.3 to 1.5 mU/L; in patient 2, from 2.0 to 0.5 mU/L. The peak TSH response to TRH stimulation decreased from 144 to 12.5 mU/L in patient 1 and from 14.2 to 2.8 mU/L in patient 2. Serum T4 decreased from 160 to 109 nmol/L in patient 1 and from 270 to 192 nmol/L in patient 2. ACE levels were persistently elevated in both patients. Resting energy expenditure, measured by oxygen consumption, was increased by Triac in both patients (12% in patient 1 and 9% in patient 2). Although Triac suppressed TSH and T4 secretion in both patients, it did not reduce peripheral action of thyroid hormone as expressed in STI, resting energy expenditure, and ACE. We conclude that in these two patients with resistance to thyroid hormone, at the doses used to suppress TSH and T4 secretion, the intrinsic peripheral action of Triac offset whatever decrease in thyroid hormone secretion it produced.
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